Introduction

The vagina is an organ that is an important to women as it is a source of pleasure but also a source of potential pain. It is open to the outside and located near the anus where the number of potentially pathogenic bacteria is large. In the body, needed for the protection system of vaginal to prevent the proliferation of pathogens. While this protection system already exists, in any case, vaginal is present in discomfort zone from frequent causes than for visiting gynecologists. This protection system is based on maintenance of acidic pH 3.5 to 4.5 where do not find the favorable conditions to proliferate by common and potentially pathogenic saprophytes while in an ideal environment, acidophilus bacilli are found. In these environments, acidophilus bacilli highly metabolize and produce large amounts of lactic acid by glucose anaerobic fermentation. Preventing the uncontrolled growth of bacteria that are present in the vagina by using the acidic pH of lactic acid that’s creating a virtuous circle.

Lactobacillus species is a variety that is dominated the healthy human vagina which plays an essential role in protecting women from genital infection. In the deficiency of lactobacilli, can upset the microbial balance in the vagina which show the syndrome of bacterial vaginosis (BV) that is linked with a quantitative and qualitative shift from normally occurring lactobacilli to a mixed microflora dominated by anaerobic bacteria. It is considered a natural part of vaginal tract and beneficiary to its healthy status. The vagina is protected against pathogens by producing antimicrobials such as bacteriocins, hydrogen peroxide and weak organic acids like acetic acid and lactic acid.

Microbial population is described by the concept of “normal microbiota” as a static that is in need of revision, particularly as better information (including that obtained through developed molecular methodologies that are not dependent on cultural) which changing the present paradigm. With the ability to maintain vaginal health, it is recognized that a spectrum of microbial profiles can produce a stable vaginal ecosystem without submitting to disease. These microbial species inhibit the vaginal tract that plays an important role in the maintenance of health and prevention of infection. In the vagina, the presence of high numbers of lactic acid bacteria (LAB) that is frequently equated with “healthy” and low number or absence, as being “abnormal”.

By the administration of antibiotics, urogenital infections can be treated with the undesirable effects of decreasing the number of lactobacilli that cannot restore the urinary tract natural barrier to infections and raise drug resistance. Around 1940, introduce by antibiotics that have many pathogens which developed

antimicrobial drug resistance mechanisms. In clinical isolates, different mechanisms of resistance have been identified including modification of drugs, alteration of drug and reduced access of drug to the intracellular target. Reduced access form of drugs from many micro-organisms that was found to be the result of active drug efflux systems. These so-called multi-drug resistance systems (MDRs) that are mainly responsible for intrinsic or acquired resistance of micro-organisms to anti-microbial drugs. The drug can have side effects including disruption of the protective vaginal microbiota which creates the high risk of urinary tract infections (UTI) and yeast vaginitis.