Authors
Vipul Joshi
Abstract
The notion of transporting genes to tissues for medical uses and implementations has been debated for almost half a century and advancement in biotechnology have introduced gene treatment to the vanguard of medicinal learning. The transference of genetic matter to treat sicknesses or to advance the medical position of a patient is termed as Gene Therapy. The elementary ideas of gene treatment is to alter viruses into genomic transports, which will transport the gene of importance onto the aimed cells. Depending up on the behavior of the virus-related genome, these gene treatment courses can be distributed into DNA and RNA virus-related courses. Gene transferal procedures have been appropriate for use of human in hereditary ailments, cancers and attained ailments. Gene therapy has not provided any everlasting treatment to any human patients, a revolution may come anytime. This paper discusses an overview of gene therapy and the extents of noteworthy advancement and evolution in this arena with the resolution of recognizing durable developments in both research as well as practice activities. Keywords: Gene Therapy, Clinical, Diseases, Biotechnology
Introduction
“We used to think that our fate was in our stars, but now we know, in large measures, our fate is in our genes” -James Watson
Genes are the purposeful unit of genetics, and are precise order bases that encrypt commands to generate proteins. If there is any sort of fluctuation in gene, encrypted proteins are incapable to handle their standard purposes, resultant in genetic syndromes (Mishra, 2013). Gene treatment fundamentally, is described as nucleic-acid grounded therapy, or transference of RNA/DNA to somatic target cells with an objective to cure deadly sicknesses. It is principally to precise imperfect genes accountable for genetic ailment.
The rudimentary perceptions of gene treatment is to transmute viruses into hereditary transports that would transport the gene of concentration onto the aimed cells. On the basis of the behavior of the virus-related genome, the course of gene treatment could be separated into DNA and/or RNA virus-related courses. From retroviruses like murine leukemia virus the popular of RNA virus based courses have been consequent. The most frequently used DNA virus courses are centered on adeno-associated viruses and adenoviruses (AAVs) Akhtar et al. (2011).
References
Anaya-Ruiz, Maricruz, and Martin Perez-Santos. “Innovation Status of Gene Therapy for Breast Cancer.” Asian Pacific Journal of Cancer Prevention, vol. 16, no. 9, 2015, pp. 4133–4136.
COTRIM, ANA P, and BRUCE J BAUM. “Gene Therapy: Some History, Applications, Problems, and Prospects.” TOXICOLOGIC PATHOLOGY, vol. 36, no. 1, 2008, pp. 97–103.
Handy, Chalonda R., et al. “Gene Therapy: A Potential Approach for Cancer Pain.” Pain Research and Treatment, vol. 2011, 2011, pp. 1–12
Najmul Hasan, and Savita Saini. “Gene Therapy: Current Status and Future Perspectives.” International Journal of Pharma Sciences and Research, vol. 5, 9 Sept. 2014, pp. 586–593.
Naveed Akhtar, et al. “Gene Therapy: A Review.” Journal of Medicinal Plants Research, vol. 5, 14 Mar. 2011, pp. 1812–1817.
PATIL, P M, et al. “REVIEW ARTICLE ON GENE THERAPY.” International Journal of Genetics, vol. 4, no. 1, 15 Mar. 2012, pp. 74–79.
Sanjukta Misra. “Human Gene Therapy: A Brief Overview of the Genetic Revolution.” JAPI, vol. 61, Feb. 2013, pp. 41–47.
Staff, Anne Cathrine. “An Introduction to Gene Therapy and Its Potential Prenatal Use.” Acta Obstetricia Et Gynecologica Scandinavica, vol. 80, no. 6, 2001, pp. 485–491.
Thomas Wirth, and Seppo Ylä Herttuala. “Gene Therapy Used in Cancer Treatment.” Biomedicines, vol. 2, 8 Apr. 2014, pp. 149–162.
Touchefeu, Y., et al. “Review Article: Gene Therapy, Recent Developments and Future Prospects in Gastrointestinal Oncology.” Alimentary Pharmacology & Therapeutics, vol. 32, no. 8, 2010, pp. 953–968.
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| APA Style | Joshi, V. (2019). Human Gene Therapy: An Overview. Academic Journal of Biotechnological Research, 1(1), 7-10. |
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